What Is The Difference Between Aspirin And Paracetamol?

1. (as above)
2. Which category(aspirin/paracetamol) does panadol and tylenol fall under?
Thanks in advance!! 😀.

2 thoughts to “What Is The Difference Between Aspirin And Paracetamol?”

  1. 1. Aspirin and paracetamol are both used as mild analgesics (painkillers) and antipyretics (fever-reducing), but their other effects differ. Aspirin reduces inflammation, which paracetamol does not, and so aspirin is often spoken of as a non-steroidal anti-inflammatory drug (NSAID). Aspirin has an effect on blood platelets, preventing them aggregating. This is a useful effect on preventing clotting in the coronary arteries causing a heart attack, so low dose aspirin is prescribed to individuals at risk of coronary events. Aspirin works by preventing the generation of prostaglandins, which are chemicals causing inflammatory reactions. Paracetamol does not share this property. Indeed its mode of action is still under discussion, but it probably works mainly on receptors in the brain.
    Which is the better drug? Both are effective for milder pains (headaches, bruises, early arthritis) and aspirin is obviously better if the pain is associated with inflammation, but otherwise it is a question of which side-effects are important to any individual. Aspirin should never be given to children, because of the possibility of Reye’s syndrome, a rare but very dangerous cause of coma and death. It is also apt to cause gastric irritation. On the other hand in overdose aspirin is far safer and easier to treat than paracetamol. Paracetamol overdose is one of the major causes of liver failure.
    2. Panadol is a trade name for paracetamol. Tylenol is a (North American) trade name for a series of tablets containing combinations of paracetamol (known as acetaminophen in the USA), codeine and caffeine in varying amounts. At least one similar combination is available in the UK (Syndol), but I am not going to recommend it.

  2. 1. They are both non-steroidal anti-inflammatory drugs however paracetamol is kinder on the stomach than aspirin. Since aspirin is an anti-inflammatory it irreversibly inhibits the cyclooxygenase enzyme that is used to convert arachodonic acid to prostaglandins. Since prostaglandins sensitise sensory nerves inhibition of this will prevent pain however it will also cause stomach ulcers because it thins the mucosal lining of the stomach by preventing prostaglandin synthesis. Paracetamol however is a non-competitive inhibitor of the cyclooxygenase enzyme and it mops up the free radicals needed as a cofactor for prostaglandin synthesis which prevents the sensitisation of sensory nerves and therefore pain.
    I hope that helps and i am sorry but i don’t know the answer to question 2. Try looking in rang and dale pharmacology it is a good source to use.

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